Down at the speeds this thing is designed for (sub-15mph) the aerodynamics, as such, would be more concerned with the effect of cross winds I'd have thought. Having the sides open might be essential to stop the thing being blown sideways into oncoming traffic............
The openings would certainly increase the Cd by a bit, but not, perhaps, by as much as you might think. I've flown with the doors on and off in the same, approximately 70mph cruise, light aircraft and the extra power doors off was only around 10% or so (it was a bit windy in the cockpit, mind..............).
I'm pretty sure that Sinclair's objective isn't aerodynamics but providing a modicum of weather protection in city traffic. I doubt it's that effective. A friend (well, the instructor I did my seaplane rating with) is currently pedalling across America in an enclosed/partially enclosed trike (
http://breenmachineworldtour.blogspot.com/). He can at least roll down side covers in really bad weather, plus he's made an effort to get the drag when fully enclosed down a bit. Here's a photo:
Gerry can get away with side screens because his creation is a trike, but if you want to build a fully enclosed two wheeler, like Cedric's, then you need more area at the rear than the Sinclair things got, to move the lateral centre of pressure back so that it's more in line with the centre of gravity. That way, when it gets hit by a side wind it won't tend to turn either away from the wind (lateral C of P forward of the C of G) or into the wind (lateral C of P aft of the C of G).
Jeremy